254 research outputs found

    L. Anneo Seneca ilustrado en blasones politicos y morales y su impugnador impugnado de si mismo...

    Get PDF
    Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-2010Fe de erratas fechada en 1671Sign.: [parágrafo]-4[parágrafo]4, A-Z4, 2A-2Y4, [parágrafo]4La h. de grab. calc.: "P. a Villafranca... sculp. Matriti 1671", retrato de D. Juan de AustriaLos grab. calc.: "Orozco Presbiter" y "Diego Obregon inv. y esculpsi

    Effectiveness and persistence of golimumab as a second biological drug in patients with spondyloarthritis

    Get PDF
    This observational, longitudinal retrospective, noncomparative study was designed to assess the persistence and effectiveness of golimumab as a second anti-tumor necrosis factor (TNF) drug in patients with spondyloarthritis requiring discontinuation from a first anti-TNF drug.Data were collected retrospectively for all patients with axial spondyloarthritis or psoriatic arthritis from 20 rheumatology clinics in Spain who started golimumab as a second anti-TNF drug between January 2013 and December 2015. Golimumab persistence was assessed with Kaplan-Meier survival analysis, and associated factors were assessed with Cox regression analysis.210 patients started golimumab as a second anti-TNF drug: 131 with axial spondyloarthritis and 79 with psoriatic arthritis. In axial spondyloarthritis patients, the mean (standard deviation) Bath Ankylosing Spondylitis Disease Activity Index score at baseline was 5.5 (2.1), decreasing to 3.9 (2.0) at month 3 and 3.5 (2.0) at year 1, and remaining stable thereafter. In psoriatic arthritis patients, mean (standard deviation) baseline Disease Activity Score was 4.0 (1.3), reducing to 2.5 (1.2) at month 3 and to 2.2 (1.3) at year 1. Corresponding improvements were recorded from baseline in C-reactive protein levels and erythrocyte sedimentation rates. The probability of persistence of treatment with golimumab was 80% at year 1, 70% at year 2 and 65% at years 3 and year 4, and was similar in those who had stopped the first anti-TNF due to loss of efficacy or other reasons. Cox regression analysis showed that the probability of survival with golimumab was higher in patients with higher erythrocyte sedimentation rate, in patients with axial spondyloarthritis than with psoriatic arthritis, and in those who had discontinued adalimumab as first anti-TNF. Seventy-two patients (34.3%) discontinued golimumab during follow-up, 50 of them due to lack of efficacy.In patients with spondyloarthritis requiring discontinuation from a first anti-TNF drug, treatment with golimumab was effective and showed a high probability of persistence up to 4 years of treatment

    Variaciones en el ph de la rizosfera y en el porcentaje de materia seca de vicia sativa al aplicar dos fuentes fosfatadas de baja solubilidad en un andisol del departamento de nariño, colombia

    Get PDF
    En el estudio se utilizaron seis tratamientos: el testigo (T0), sin fuentes fosfatadas (T1) y con adiciones de 25 y 50 kg/ha de P como fosforita Huila (T2 y T3) y calfós (T4 y T5). Los cambios generados por la raíz se evaluaron utilizando la solución nutritiva de Marschner Römheld y Ossenberg-Neuhaus, acondicionada con agar. El porcentaje de materia seca parcial de Vicia sativa se incrementó significativamente al aplicar 25 y 50 kg/ha de P como fosforita Huila (T2 y T3) y calfos (T5 y T6) en la localidad de Genoy. El pH de la solución agarizada sufrió disminuciones significativas a través del tiempo especialmente en los tratamientos T3 y T2.Palabras claves: pH rizosférico, Vicia sativa, Papilionoidea, fuentes fosfatadas, solubilida

    High Frequency Inductive Power Transfer Through Soil for Agricultural Applications

    Get PDF
    This work was supported by the UK Research and Innovation (UKRI), reference numbers: NE/ T011467/1 and NE/T011068/1, and the National Science Foundation (NSF), award no. 1935632: SitS NSF-UKRI: Wireless In-Situ Soil Sensing Network for Future Sustainable Agriculture’. (Corresponding author: Juan M. Arteaga.)Peer reviewedPublisher PD

    Metabolic alterations, HFE gene mutations and atherogenic lipoprotein modifications in patients with primary iron overload

    Get PDF
    Abstract Iron overload (IO) has been associated with glucose metabolism alterations and increased risk of cardiovascular disease (CVD). Primary IO is associated with mutations in the HFE gene. To which extent HFE gene mutations and metabolic alterations contribute to the presence of atherogenic lipoprotein modifications in primary IO remains undetermined. The present study aimed to assess small, dense low-density lipoprotein (LDL) levels, chemical composition of LDL and high-density lipoprotein (HDL) particles, and HDL functionality in IO patients. Eighteen male patients with primary IO and 16 sex-and age-matched controls were recruited. HFE mutations (C282Y, H63D and S65C), measures of insulin sensitivity and secretion (calculated from the oral glucose tolerance test), chemical composition and distribution profile of LDL and HDL subfractions (isolated by gradient density ultracentrifugation) and HDL functionality (as cholesterol efflux and antioxidative activity) were studied. IO patients compared with controls exhibited insulin resistance (HOMA-IR (homoeostasis model assessment-estimated insulin resistance): +93 %, P < 0.001). Metabolic profiles differed across HFE genotypes. C282Y homozygotes (n = 7) presented a reduced β-cell function and insulin secretion compared with non-C282Y patients (n = 11) (−58 % and −73 %, respectively, P < 0.05). In addition, C282Y homozygotes featured a predominance of large, buoyant LDL particles (C282Y: 43 + − 5; non-C282Y: 25 + − 8; controls: 32 + − 7 %; P < 0.001), whereas non-C282Y patients presented higher amounts of small, dense LDL (C282Y: 23 + − 5; non-C282Y: 39 + − 10; controls: 26 + − 4 %; P < 0.01). HDL particles were altered in C282Y homozygotes. However, HDL functionality was conserved. In conclusion, metabolic alterations and HFE gene mutations are involved in the presence of atherogenic lipoprotein modifications in primary IO. To what extent such alterations could account for an increase in CVD risk remains to be determined
    • …
    corecore